BioNanotechnology Seminar Series - Fall 2014

Using arrays of silicon photonic microring resonators for the multiplexed detection of microRNAs relevant to Glioblastoma multiforme subclassification
Richard M. Graybill , Chemistry

Wednesday, September 17, 2014
1000 MNTL, 12:00 - 12:30 PM

Abstract: The methods used to study microRNAs (miRNAs) involved in cancer have failed to keep pace with our understanding of cancer pathology and are imperfect fits for the clinic. qRT-PCR, the current gold standard, is sensitive, rapid, and cost effective, but only able to quantitate one target per sample volume. Conversely, microarrays can interrogate all known miRNA sequences, but take days to complete. As a result, there is no clinically adopted technology for the multiplexed detection of miRNAs. Here we show that a platform utilizing arrays of silicon photonic microring resonators can fill the void left by current miRNA analysis techniques by simultaneously quantitating 25 miRNAs relevant to Glioblastoma multiforme (GBM) and show that these results correlate well with qRT-PCR.

In these studies, we use GBM, an extremely invasive glioma subtype with a mean survival time of 12-14 months, as a model system. mRNA and protein profiling have helped identify underlying GBM biology and potential targets for new therapies; however, over the past few decades, survival outcomes and therapeutic strategies have not changed. As a result, researchers have begun to investigate miRNAs as a potential solution. In doing so, multiplexed miRNA biopanels have emerged that are predictive of GBM grade, recurrence, and survival. This abstract displays a validated microring resonator technology that is easily translatable to the clinic and facilitates the detection of a GBM-specific meso-plex miRNA biomarker panel.

 

NanoSTRuCT K-12: Nanoscale Science and Technology Resources for
Community Teaching in K-12

Alexander Cerjanic and Brittany Renee Weida, Bioengineering

Wednesday, September 17, 2014
1000 MNTL, 12:30 - 1:00 PM

Abstract: NanoSTRuCT is a student-organized project to develop and refine activities for bringing nanoscale science to community classrooms. As a student-led project, students and trainees have begun to lay the foundation for an ongoing and sustainable project including planning, resource development, and grant-writing. Brittany Weida and Alex Cerjanic will present the upcoming NanoSTRuCT project to work with 3rd grade students from Booker T. Washington STEM Academy. This presentation and discussion will be your opportunity to see what is going on with outreach and how you can be involved in the upcoming project to not only engage in fun outreach activities, but participate in useful career-building activities such as project management and grant-writing.

 

Trigger Responsive Camptothecin Conjugate for High Loading Nanoencapsulates
Kaimin Cai, Materials Science and Engineering

Wednesday, October 1, 2014
1000 MNTL, 12:00 - 12:30 PM

Abstract: Polymeric micelle is one of the most widely used drug delivery nanomedicine platforms; however, micelle drug delivery systems usually have very low drug loading and poorly defined composition, which greatly limited its further clinical translation. In the course of developing trigger responsive camptothecin conjugates, we discovered an unprecedented approach to prepare core-shell structured drug encapsulates. The polymeric nanoparticles have extremely high drug loading, quantitative loading efficiency as well as controlled release profile responsive to stimuli. Formulation studies indicated a non-micellar mechanism for nanoparticle formation instructing a completely new approach for polymeric nanoparticle design. Both in vitro and in vivo studies showed excellent therapeutic efficacy for cancer treatment. We believe that our strategy provides a new route to encapsulate hydrophobic drugs efficiently without complicated carrier polymer syntheses and screening.

 

Electronic Point of Care Sensors for Multiplexed Monitoring of Biological Entities
Bobby Reddy, Postdoc in the Micro and Nanotechnology Lab at the University of Illinois at Urbana-Champaign

Wednesday, October 1, 2014
1000 MNTL, 12:30 - 1:00 PM

Abstract: Our world has experienced an unprecedented level of digitalization at the personal level over the past decade. Companies such as Google, Apple, and Facebook are collecting terabytes upon terabytes of diverse data with individual specific information for billions of people across the globe. However, health care data has lagged significantly behind this trend. There will be a huge opportunity over the next decade to democratize and personalize health care to tailor treatment and diagnosis approaches to individual patients. One of the critical components of this vision are diagnostic sensors that are convenient, user-friendly, accurate, and cost effective enough to dramatically increase the frequency of health diagnostic tests. This talk will describe initial efforts towards building a true electronic point-of-care sensor capable of monitoring hundreds of important biological entities, including cells, viruses, nucleic acids, and proteins, from a finger prick of blood. The use of “first degree sensing”, where the output signal is transduced from intrinsic properties of the target analyte instead of from subsequent modification steps, offers tremendous potential for simplification of diagnostic tests. These sensors may offer the only feasible approach for truly miniaturized, cost effective, and minimally invasive diagnostic techniques towards the goal of convincing billions of people around the world to actively collect increasingly critical information about their health.

 

Title
Speaker, Department

Wednesday, October 29, 2014
1000 MNTL, 12:00 - 1:00 PM

Abstract: TBD.

 

Title
Speaker, Department

Wednesday, November 12, 2014
1000 MNTL, 12:00 - 1:00 PM

Abstract: TBD.

 

Title
Speaker, Department

Wednesday, December 3, 2014
1000 MNTL, 12:00 - 1:00 PM

Abstract: TBD.