BioNanotechnology Seminar Series - Fall 2014

Using arrays of silicon photonic microring resonators for the multiplexed detection of microRNAs relevant to Glioblastoma multiforme subclassification
Richard M. Graybill , Chemistry

Wednesday, September 17, 2014
1000 MNTL, 12:00 - 12:30 PM

Abstract: The methods used to study microRNAs (miRNAs) involved in cancer have failed to keep pace with our understanding of cancer pathology and are imperfect fits for the clinic. qRT-PCR, the current gold standard, is sensitive, rapid, and cost effective, but only able to quantitate one target per sample volume. Conversely, microarrays can interrogate all known miRNA sequences, but take days to complete. As a result, there is no clinically adopted technology for the multiplexed detection of miRNAs. Here we show that a platform utilizing arrays of silicon photonic microring resonators can fill the void left by current miRNA analysis techniques by simultaneously quantitating 25 miRNAs relevant to Glioblastoma multiforme (GBM) and show that these results correlate well with qRT-PCR.

In these studies, we use GBM, an extremely invasive glioma subtype with a mean survival time of 12-14 months, as a model system. mRNA and protein profiling have helped identify underlying GBM biology and potential targets for new therapies; however, over the past few decades, survival outcomes and therapeutic strategies have not changed. As a result, researchers have begun to investigate miRNAs as a potential solution. In doing so, multiplexed miRNA biopanels have emerged that are predictive of GBM grade, recurrence, and survival. This abstract displays a validated microring resonator technology that is easily translatable to the clinic and facilitates the detection of a GBM-specific meso-plex miRNA biomarker panel.

NanoSTRuCT K-12: Nanoscale Science and Technology Resources for
Community Teaching in K-12

Alexander Cerjanic and Brittany Renee Weida, Bioengineering

Wednesday, September 17, 2014
1000 MNTL, 12:30 - 1:00 PM

Abstract: NanoSTRuCT is a student-organized project to develop and refine activities for bringing nanoscale science to community classrooms. As a student-led project, students and trainees have begun to lay the foundation for an ongoing and sustainable project including planning, resource development, and grant-writing. Brittany Weida and Alex Cerjanic will present the upcoming NanoSTRuCT project to work with 3rd grade students from Booker T. Washington STEM Academy. This presentation and discussion will be your opportunity to see what is going on with outreach and how you can be involved in the upcoming project to not only engage in fun outreach activities, but participate in useful career-building activities such as project management and grant-writing.

 

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Wednesday, October 1, 2014
1000 MNTL, 12:00 - 1:00 PM

Abstract: TBD.

 

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Wednesday, October 15, 2014
1000 MNTL, 12:00 - 1:00 PM

Abstract: TBD.

 

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Wednesday, October 29, 2014
1000 MNTL, 12:00 - 1:00 PM

Abstract: TBD.

 

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Wednesday, November 12, 2014
1000 MNTL, 12:00 - 1:00 PM

Abstract: TBD.

 

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Wednesday, December 3, 2014
1000 MNTL, 12:00 - 1:00 PM

Abstract: TBD.